Description
Thujone (/ˈθuːdʒoʊn/ ([2]) is a ketone and a monoterpene that occurs predominantly in two diastereomeric (epimeric) forms: (−)-α-thujone and (+)-β-thujone.[3][4] Though it is best known as a chemical compound in the spirit absinthe, it is unlikely to be responsible for absinthe’s alleged stimulant and psychoactive effects due to the small quantities present. Thujone acts on GABA as an antagonist (opposite to the effects of alcohol). As a competitive antagonist of GABA, thujone alone is considered to be convulsant,[5] though by interfering with the inhibitory transmitter GABA, it may convey stimulating, mood-elevating effects at low doses. It is also used in perfumery as a component of several essential oils.
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